X chromosomal monosomy with bilateral ovotestes in a Labrador Retriever dog

Hayley Hunt; Michael Yaeger; Amanda Fales-Williams; Sharon Wagner; Eleas Wu; Theresa Beachler

doi:10.58292/CT.v17.11198

Hayley Hunt Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
Michael Yaeger Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
Amanda Fales-Williams Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
Sharon Wagner Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
Eleas Wu Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
Theresa Beachler Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA

DOI: https://doi.org/10.58292/CT.v17.11198

Keywords: Dogs, sexual development, ovotestis, X chromosomal monosomy

Abstract

A 2 year intact, phenotypically female Labrador Retriever dog was presented for evaluation of persistent white vaginal discharge after a perceived normal estrous cycle. On repeat evaluations, the dog was determined to be in persistent cytologic estrus ~ for 2 months. Abdominal ultrasonography revealed suspected bilateral ovarian cysts and cystic endometrial hyperplasia. After ultrasound-guided cystic aspiration, the dog was treated with a 3 day course of gonadotropin-releasing hormone (GnRH). Four months after initial treatment, the dog developed behavioral and physical signs of estrus that lasted ~ for 4 weeks; systemic progesterone concentrations never increased > 1.0 ng/ml. Repeat abdominal ultrasonography revealed another cyst-like structure on the right gonad. Similar treatment (cyst aspiration and GnRH treatment) was given. Paired cystic fluid and blood serum hormone concentrations were analyzed at each aspiration; testosterone concentrations were higher in serum and cystic fluid. Ovariohysterectomy and karyotyping diagnoses were bilateral ovotestis and X chromosomal monosomy (77, XO).

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