Disorders of sexual development: a case of XX sex reversal in a mixed breed dog negative for SRY (sex-determining region on the Y chromosome) gene

  • Kelsey Martin Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins, CO
  • Agata Parsons Department of Biomedical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins, CO
  • Greg Burns Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins, CO
  • Gerrit Bouma Department of Biomedical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins, CO
  • Fiona Hollinshead Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins, CO
DOI: https://doi.org/10.58292/ct.v14.9141
Keywords: Phenotypic sex, antimüllerian hormone, sex reversal

Abstract

An 8-month mixed breed dog (from shelter) was evaluated for its abnormal external genital (enlarged os clitoris protruding externally from the vulva) condition. Dog had phenotypic female appearance. Testicular-like tissue was removed via laparoscopy-assisted gonadectomy. Genotype was determined using blood and gonadal tissue (via histology and immunohistochemistry). Dog had XX chromosomes and was negative for SRY (sex-determining region on the Y chromosome) gene.

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Published
2022-06-01
How to Cite
Martin K., Parsons A., Burns G., Bouma G., & Hollinshead F. (2022). Disorders of sexual development: a case of XX sex reversal in a mixed breed dog negative for SRY (sex-determining region on the Y chromosome) gene. Clinical Theriogenology, 14(2), 110-114. https://doi.org/10.58292/ct.v14.9141
Issue
Vol. 14 No. 2 (2022): June
Section
Case Reports
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