Granulosa Cell Tumor In A Heifer: Clinical, Ultrasonographic, Endocrine And Pathologic Findings

Abstract

An 18-month-old 652-kg black Limousin heifer was evaluated because of an enlarged left ovary and infertility following herd pregnancy examination. The heifer had been treated for cystic ovarian disease, however the left ovary remained enlarged. Palpation per rectum revealed a firm, multilobulated mass in the region of the left ovary. Transrectal ultrasonography confirmed a large, hypo- to anechoic polycystic left ovary. Hormone assays showed an increase in estrogens and inhibin, normal or slightly elevated concentration of testosterone, and a low concentration of progesterone. A left ovariectomy via ventral midline celiotomy was performed. Gross and histopathologic evaluation of the mass confirmed a granulosa cell tumor (GCT). Six months after surgery, the heifer was found dead in the pasture due to causes unrelated to surgery. Necropsy revealed the remaining right ovary had grown in size, suggesting the beginning of follicular activity.