Canine Sertoli cell tumor: anti-Müllerian hormone, inhibin B, and estrone sulphate

  • Fiona Herzog Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA
  • Daniella Adams Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA
  • Alissa St. Blanc Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA
  • Jeongha Lee Department of Pathobiological Sciences and Louisiana Animal Disease Diagnostic Laboratory, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA
  • Ingeborg Langohr Department of Pathobiological Sciences and Louisiana Animal Disease Diagnostic Laboratory, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA
  • Carlos Pinto Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA
Keywords: Cryptorchidism, feminization, paraneoplastic syndrome


A unilaterally castrated male boxer was referred for chronic generalized alopecia and pruritus. Physical examination revealed symmetrical alopecia, pendulous prepuce, lichenification of the scrotum, and enlargement of mammary papillae. Penile/preputial cytology revealed superficial epithelial cells. Transabdominal ultrasonographic examination revealed a globoid mass with heterogenous echogenicity in the left caudal abdomen. The presumptive diagnosis was Sertoli cell tumor (SCT) associated with cryptorchidism. Exploratory laparotomy and histology of the removed mass confirmed the diagnosis. Three weeks after surgery, serum anti-Müllerian hormone (AMH) concentrations decreased from 8,435 to 56 ng/ml and inhibin B decreased from 805 to < 6 pg/ml. Two months after surgery dermatoses subsided and there was substantial regression of enlarged nipples. This report highlights the diagnostic value of practical procedures (penile/preputial cytology, transabdominal ultrasonography, and measurement of serum AMH and inhibin B concentrations) to aid in the diagnosis of cryptorchidism and SCT, especially in patients with generalized skin conditions.


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How to Cite
Herzog F., Adams D., St. Blanc A., Lee J., Langohr I., & Pinto C. (2023). Canine Sertoli cell tumor: anti-Müllerian hormone, inhibin B, and estrone sulphate. Clinical Theriogenology, 15.
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