Use of a direct-to-consumer genetic screening test for diagnosis of a chromosomal abnormality in a female dog

  • Jenna Dockweiler Embark Veterinary, Inc., Boston, MA, USA
  • Valeria Rickard North Oatlands Animal Hospital, Leesburg, VA, USA
  • Daniel Leon-Frank North Oatlands Animal Hospital, Leesburg, VA, USA
  • Christopher Premanandan Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University Columbus, OH, USA
  • Adam Boyko Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
  • Takeshi Kawakami Embark Veterinary, Inc., Boston, MA, USA
DOI: https://doi.org/10.58292/CT.v17.12703
Keywords: Microarray, chromosomal anomaly, genetic, genetic test, DNA test

Abstract

A 3-year phenotypically female Siberian husky with primary anestrus, was screened for known genetic diseases using a direct-to-consumer saliva test. Dog had 2 distinct genetic profiles, suggesting a chimera or mosaic condition, ultimately confirmed with cytogenetic analysis. Histopathology of the intraabdominal gonads revealed hypoplastic testicular and epididymal tissue. This case highlights the utility of a novel test that is both inexpensive and noninvasive to diagnose chromosomal anomalies in dogs.

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Published
2025-11-20
How to Cite
Dockweiler , J., Rickard , V., Leon-Frank , D., Premanandan , C., Boyko , A., & Kawakami , T. (2025). Use of a direct-to-consumer genetic screening test for diagnosis of a chromosomal abnormality in a female dog. Clinical Theriogenology, 17. https://doi.org/10.58292/CT.v17.12703
Issue
Vol. 17 (2025)
Section
Case Reports
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