Staphylococcus pseudintermedius causing presumptive ascending canine abortion
Keywords:
Dog, Staphylococcus pseudintermedius, abortion, ascending infection
Abstract
Despite growing literature regarding evidence of commensal and sometimes pathogenic bacteria in the uterine and vaginal microbiome of dogs, no direct association with reproductive disease has been linked to Staphylococcus pseudintermedius, an opportunistic vaginal commensal (commonly cultured). A multiparous dog had an infectious abortion during late pregnancy over the course of a week. The infectious agent identified on fetal autopsy via culture of the stomach contents and spleen was Staphylococcus pseudintermedius.
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References
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24. Zareba-Szczudlik J, Romejko-Wolniewicz E, Lewandowski Z, et al: Evaluation of the amoxicillin concentrations in amniotic fluid, placenta, umbilical cord blood and maternal serum two hours after oral administration. Neuroendocrinol Lett 2017;38:502–508.
25. Uchańska O, Ochota M, Eberhardt M, et al: Dead or alive? A review of perinatal factors that determine canine neonatal viability. Animals 2020;12:5–6. https://doi.org/10.3390/ani12111402
26. Wynn MAA, Esteller-Vico A, Legacki EL, et al: A comparison of progesterone assays for determination of peripheral pregnane concentrations in the late pregnant mare. Theriogenology 2018;106:127–133. https://doi.org/10.1016/j.theriogenology.2017.10.002
27. APP. Gentamicin injection, USP [Fact Sheet]. U.S. Department of Food & Drug Association; 2013. [cited 2023 October 14]. Available from: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/062366s033lbl.pdf
2. Groppetti D, Pecile A, Barbero C, et al: Vaginal bacterial flora and cytology in proestrous bitches: role on fertility. Theriogenology 2012;77:1549–1556. https://doi.org/10.1016/j.theriogenology.2011.11.022
3. Stockner PK, Baker D: Canine vaginal flora: a technique for sampling and clinical observation. Canine Pract 1979;6:18–22.
4. Lynch SA, Helbig KJ: The complex diseases of Staphylococcus pseudintermedius in canines: where to next? Vet Sci 2021;8:1–7. https://doi.org/10.3390/vetsci8010011
5. Hutchins RG, Vaden SL, Jacob ME, et al: Vaginal microbiota of spayed dogs with or without recurrent urinary tract infections. J Vet Intern Med 2014;28:300–304. https://doi.org/10.1111/jvim.12299
6. Hutchins RG, Bailey CS, Jacob ME, et al: The effect of oral probiotic supplementation on the vaginal microbiota of spayed female dogs. J Vet Intern Med 2013;27:1368–1371. https://doi.org/10.1111/jvim.12174
7. Rota A, Corro M, Patuzzi I, et al: Effect of sterilization on the canine vaginal microbiota: a pilot study. BMC Vet Res 2020;16:1–10. https://doi.org/10.1186/s12917-020-02670-3
8. Shambulingappa BE, Anand Manegar G, Ananda KJ: Study on aerobic bacterial flora in canine abortions. Vet World 2010;3:111–112.
9. Lyman CC, Holyoak GR, Meinkoth K, et al: Canine endometrial and vaginal microbiomes reveal distinct and complex ecosystems. PLoS One 2019;14:1–17. https://doi.org/10.1371/journal.pone.0210157
10. Khandekar GS, Gaikwad SV, Choudhari KE, et al: Bacterial isolation after ovariohysterectomy for selection of antibacterials in canine pyometra. Intas Polivet 2015;16:235–237.
11. Sanť Anna MC, Fabretti AK, Martins MIM: Clinical approach to canine vaginitis. Semina: Londrina 2012;33:1544. https://doi.org/10.5433/1679-0359.2012v33n4p1543
12. Bjurström L: Aerobic bacteria occurring in the vagina of bitches with reproductive disorders. Acta Vet Scand 1993;34:29–34. https://doi.org/10.1186/BF03548220
13. Johnston SD, Root Kustritz MV, Olson PNS: Canine and feline theriogenology. 1st ed. Philadelphia, PA: Saunders; 2001, p. 43, p. 66–69, 87–95.
14. Gunzel-Apel A, Urhausen C, Wolf K, et al: Serum progesterone in pregnant bitches supplemented with progestin because of expected or suspected luteal insufficiency. Reprod Domest Anim 2012;47:55–60. https://doi.org/10.1111/rda.12029
15. Gruyter DE, Carp HJA: Progestogens in the prevention of miscarriage. Horm Mol Biol Clin Invest 2016;27:55–62. https://doi.org/10.1515/hmbci-2015-0058
16. Gruyter DE, Carp HJA: Progestins in luteal support. Horm Mol Bio Clin Invest 2020;42:143–148. https://doi.org/10.1515/hmbci-2019-0067
17. Carp HJA: Progestogens and pregnancy loss. Climacteric 2018; 21:380–384. https://doi.org/10.1080/13697137.2018.1436166
18. Graubner FR, Tavares Pereira M, Boos A, et al: Canine decidualization in vitro: extracellular matrix modification, progesterone mediated effects and selective blocking of prostaglandin E2 receptors. J Reprod Dev 2020;66:319–329. https://doi.org/10.1262/jrd.2019-157
19. Fedorka C: Progestin use in mares. Clinical Theriogenology 2021:13;247–254.
20. Sperling S, Mitchell A, Cheong SH, et al: Singleton pregnancy with concurrent pyometra in the contralateral horn in a bitch with a live puppy outcome. Reprod Domest Anim 2018;53:1609–1612. https://doi.org/10.1111/rda.13290
21. GlaxoSmithKline. Augmentin® prescribing info [Fact Sheet]. U.S. Department of Food & Drug Association; n.d. [cited 2023 October 14]. Available from Chrome extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050575s037550597s044050725s025050726s019lbl.pdf
22. Sa Del Fiol F, Gerenutti M, Groppo FC: Antibiotics and pregnancy. Pharmazie 2005;60:483–493. https://doi.org/10.1002/chin.200540250
23. Daniel S, Doron M, Fishman B, et al: The safety of amoxicillin and clavulanic acid use during the first trimester of pregnancy. Br J Clin Pharmacol 2019;85:2856–2863. https://doi.org/10.1111/bcp.14118
24. Zareba-Szczudlik J, Romejko-Wolniewicz E, Lewandowski Z, et al: Evaluation of the amoxicillin concentrations in amniotic fluid, placenta, umbilical cord blood and maternal serum two hours after oral administration. Neuroendocrinol Lett 2017;38:502–508.
25. Uchańska O, Ochota M, Eberhardt M, et al: Dead or alive? A review of perinatal factors that determine canine neonatal viability. Animals 2020;12:5–6. https://doi.org/10.3390/ani12111402
26. Wynn MAA, Esteller-Vico A, Legacki EL, et al: A comparison of progesterone assays for determination of peripheral pregnane concentrations in the late pregnant mare. Theriogenology 2018;106:127–133. https://doi.org/10.1016/j.theriogenology.2017.10.002
27. APP. Gentamicin injection, USP [Fact Sheet]. U.S. Department of Food & Drug Association; 2013. [cited 2023 October 14]. Available from: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/062366s033lbl.pdf
Published
2023-12-29
How to Cite
Nebel-Karp A. (2023). <em>Staphylococcus pseudintermedius</em> causing presumptive ascending canine abortion. Clinical Theriogenology, 15. https://doi.org/10.58292/ct.v15.9837
Issue
Section
Case Reports
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