Single cell transcriptomics to define germ cell function in livestock

  • Jon M. Oatley School of Molecular Bioscience, College of Veterinary Medicine, Washington State University, Pullman, WA
  • Colton Robbins School of Molecular Bioscience, College of Veterinary Medicine, Washington State University, Pullman, WA
  • Michela Ciccarelli School of Molecular Bioscience, College of Veterinary Medicine, Washington State University, Pullman, WA
DOI: https://doi.org/10.58292/ct.v13.9326
Keywords: Single cell RNA sequencing, livestock, spermatogenesis, testis

Abstract

Spermatogenesis is a specialized developmental process that produces millions of sperm each day from puberty to old age. Crosstalk
among testicular germ and somatic cells provides required direction for homeostasis of spermatogenesis and regeneration after an
insult. Understanding spermatogenesis and the importance of sperm are critical. Sperm contribute genetic information that influences
the traits of offspring, thus shaping performance, resiliency, and fitness of animal populations. Recent emergence of single cell RNA
sequencing analysis (transcriptomics) opened a new avenue to explore reproductive biology by defining heterogeneity and crosstalk
within complex cell lineages (e.g. male germline). New insights in the regulation of developmental processes at a molecular level
provides invaluable information for researchers and clinicians to address underlying causes of infertility/subfertility and design novel
advanced reproductive technologies.

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Published
2021-09-01
How to Cite
Oatley J. M., Robbins C., & Ciccarelli M. (2021). Single cell transcriptomics to define germ cell function in livestock. Clinical Theriogenology, 13(3), 127-129. https://doi.org/10.58292/ct.v13.9326
Issue
Vol. 13 No. 3 (2021): September (Proceedings)
Section
Papers
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