Antimicrobial therapy in bovine reproduction

Abstract

The use of antimicrobials, both systemically and locally, has been a hallmark of 7 therapy in the treatment of uterine infections in cattle. However, the use of 8 antimicrobials has not been without controversy regarding their efficacy, effects on future 9 fertility, risk for bacterial resistance and potential residues. This article reviews the 10 immunology and pathophysiology of postpartum uterine infections in cattle and evaluates 11 research regarding the use and efficacy of local and systemic antimicrobial therapies.